066: Mike Israetel Q&A – A case for muscle damage

Another fantastic Q&A with Dr. Mike.

00:40 Elaborations on differentiation between Overload and Progressive Overload.
08:02 When we diet we want to prevent muscle loss. However post diet it’s often said we can gain back the lean tissue lost quickly due to muscle memory. Why not then diet harder?
22:18 Is there any evidence you know of that ‘functional overreaching’ results in more growth than continued progression? or any research supporting prolonged AMPK elevation phenomenon dominating over mTOR?
32:50 What are your thoughts on hyperplasia for both natural and enhanced populations?
36:18 Defending his stance on muscle damage and soreness being indicative of hypertrophy. Just recently heard some smart evidence based folks touting that muscle damage is more of a by-product of training that may even interfere with muscle gains, as opposed to something to actively seek out?
46:50 Thoughts on number of hard sets?
49:55 Where do you see yourself in 5 years and 10 years time ?

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  1. Majmun27v says:

    Has Mike sent you papers?

  2. Josh Williams says:


  3. NWCalvank says:

    I love hearing other experts discuss Menno’s work. It seems like he has an exceptional thought process up to the point of making a conclusion, and then comes up with some strange ideas, which really push other people to defend their own conclusions.

  4. Jovan Cvetojevic says:

    I love you Steve <3

  5. Mike Gaiso says:

    If anti inflammatories impede group , would pro inflammatory like arachondic acid enhance growth?

    • Joe says:

      Mike Gaiso You can feel the increased inflammatory response, but not sure if it enhances growth much, think theres some info on examine(dot)com about it

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