Kamba Wellness is a progressive CBD wellness company seeking to enhance the emotional, mental, and physical well-being of individuals and pets by providing the safest and highest quality wellness products. We thrive on bringing general education about CBD to consumers while giving back to nonprofits and communities which serve our customer base. One of our strong education points is on the endocannabinoid system (ECS). Although many schools have not taught about the ECS in the past because little was known about it, it has been recently been added to curricula around the globe to help people understand how their bodies function and the benefits of CBD.
Our bodies naturally produce cannabinoids called endogenous cannabinoids (endocannabinoids, therefore, making up our ECS. The ECS and its receptors are responsible for controlling cognitive responses such as appetite, internal balance, metabolic control functions like the storage and transport of nutrients, can act on peripheral tissues like the gastrointestinal tract, skeletal muscles, and endocrine glands. Information gathered from scientific research has shown how the use of CBD can serve to assist people and pets through the production of brain health, bone health, pain relief, enhance immune system activities, heart health, anxiety and depression, improves quality of sleep and is a possible source of alternative medicine.
It is impossible to discuss the benefits of the ECS without making references to its receptors. The cannabinoid receptors (CB1 and CB2) are the primary sites for the activity of cannabinoids. Cannabinoids are lipid-based neurotransmitters that are neither indwelling (endocannabinoids) or can be extracted from plants (phytocannabinoids). These cannabinoids are configured to interact with the active sites of CB1 and CB2 receptors to bring about therapeutic benefits.
The CB1 receptor is predominantly found in the central nervous system and other peripheral organs like the liver and pancreas. They are the primary site of action for anandamide (endocannabinoid) or tetrahydrocannabinol (THC) derived from the cannabis plant. The CB1 receptors are widely distributed in fat cells, fat, digestive system, lungs, liver, blood vessels and the heart.
The CB2 receptors are expressed as in the immune system and play active roles in the release of cytokines and other immune-based molecules. It is the primary site of activity for 2-arachidonoylglycerol (2-AG) and endocannabinoid and CBD, its phytocannabinoids counterpart. Although they are not widely distributed as the CB1 receptors, their massive presence in the gastrointestinal system, immune system and spleen have been shown to be responsible for several therapeutic benefits of CBD including energy metabolism, food intake, inflammation, pain management and the regulation of appetite. They also play a significant role when it comes to the treatment of epileptic seizures. Contrary to what is obtainable in CB1 receptors, information gathered from research has shown that dogs contain about 30 times less binding affinity than in humans and rat population. The extent of its activity is determined by the type of signaling pathways involved and the expression of cell membranes.
